Conference background Fudan’s BIG BRAIN 2022 follows on BIG BRAIN 2019 at Lomonosov Moscow State University, the first successor to BIG BRAIN 2018 in Krefeld/Duesseldorf which had emerged from EURASIAN HEALTH & MEDICINE 2018 inspired by One Continent, One Mission - Health in EurAsia and realized with Guangdong Province at SUSTech. Aims Advance scientific collaboration of long term to unleash this outstanding potential, BIG BRAIN "EurAsia's Young Science - Talented & Ambitious", on challenging research topics for lasting academic careers to benefit their own people. Scope Integration of system sciences for comprehensive research on human-body physiology and person’s behavior across variant EurAsian settings from a viewpoint of multi-scale control of internal dynamics under permanent exchange with and impact from its surroundings. Simpler language That people’s life-sphere settings vary in many aspects across EurAsia’s regions is common knowledge, but this is falsely seen as inconvenient, a nuisance, by some. Systematic variation is a valuable source of insight in experimental work, and so is variation of life-sphere exposures a most valuable pathway to study physiological processes and person’s behavioral decision in people from different regions. Goal Model the dynamics of internal processes and their controls for targeted medical interventions and optimal health preservation.